Extracellular vesicles: Their emerging roles in the pathogenesis of respiratory diseases

Alveoli are the basic structure of lungs, consisting various types parenchymal and bone marrow-derived cells including alveolar macrophages. These have several important functions; thus, communication between these plays an role in homeostasis as well pathophysiology diseases lungs. For a better understanding lung diseases, researchers isolated each type cell to investigate changes their gene expressions, humoral factor or adhesion molecules, reveal intercellular among cells. In particular, investigations during past decade focused on extracellular vesicles, which lipid bilayer delimited vesicles released from that can move transfer substances, microRNAs, mRNAs proteins, functioning messengers. Extracellular be classified into three general groups: apoptotic bodies, exosomes, microparticles. especially exosomes microparticles, attracting increasing attention pulmonologists tools for pathogenesis disease diagnosis. Here, we review studies, our own, microparticles roles both such idiopathic pulmonary fibrosis, chronic obstructive acute respiratory distress syndrome. This also addresses COVID-19, current global public health crisis.